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International Nonproprietary Name: Metronidazole / Metronidazole.
Dosage form: tablets 200 mg, 400 mg.
Description: white tablets with a greenish-yellow hue of color, flat-cylindrical, with a risk and a facet buy metronidazole over the counter.
Composition: each tablet contains: active ingredient - metronidazole - 200 mg; Auxiliary substances - talc, stearic acid, polyvinyl alcohol, potato starch. Pharmacotherapeutic group: Antimicrobial agents for systemic use. Derivatives of imidazole.
Antiprotozoal and antibacterial drug buy metronidazole otc, a derivative of 5-nitro-imidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of this drug by intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5-nitro group of flagyl over the counter reacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
It is active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (Including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp. And some Gram-positive anaerobes (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The MIC for these strains is 0.125 - 6.25 μg / ml. It shows activity against Helicobacter pylori (however, in 40% of cases it is possible to carry metronidazole-resistant strains).
Buy flagyl over the counter is insensitive to aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) where can i buy metronidazole over the counter acts synergistically with antibiotics effective against conventional aerobes. Increases the sensitivity of tumors to radiation, causes disulfiramoid-like reactions
Absorption is high (bioavailability is not less than 80%). Has a high penetrating ability, reaching bactericidal concentrations in most tissues and body fluids, including lungs, kidneys, liver, skin, cerebrospinal fluid, brain, bile, saliva, amniotic fluid, abscess cavities, vaginal secretion, seminal fluid, breast milk, penetrates through Blood-brain barrier and placental barrier. The volume of distribution: adults - about 0,55 l / kg, newborns - 0,54 - 0,81 l / kg. Cmax is from 6 to 40 μg / ml depending on the dose and is achieved after 1 to 3 hours. Communication with plasma proteins is 10-20%.
Metabolised ≈ 30-60% of buy flagyl over the counter by hydroxylation, oxidation and glucuronidation. The main metabolite (2-oxymetronidazole) also has antiprotozoal and antimicrobial effects. T1 with normal liver function - 8 hours (6 to 12 hours), with alcoholic liver damage - 18 hours (10 to 29 hours), in newborns: those born at the gestational age - 28 - 30 weeks - about 75 hours, 32 - 35 weeks, 35 hours, 36 - 40 weeks - 25 hours. It is excreted by the kidneys 60 - 80% (20% unchanged), through the intestine - 6 - 15%.
Renal clearance - 10.2 ml / min. In patients with impaired renal function after repeated administration, cumulation of buy metronidazole 500mg online in serum can be observed (therefore, the frequency of admission should be reduced in patients with severe renal insufficiency). flagyl 500 mg oral tablet and major metabolites are rapidly removed from the blood during hemodialysis (T1 / 2 is reduced to 2.6 h). When peritoneal dialysis is withdrawn in small quantities.
To avoid the development of resistance of microorganisms, buy metronidazole online should be used only for the treatment of infections caused buy flagyl online fast delivery sensitive strains (according to microbiological examination of the material or epidemiological data). Trichomoniasis with clinical symptoms - in women and men in the case of laboratory confirmation of diagnosis (smear and / or culture study).
Asymptomatic trichomoniasis - in women with endocervicitis, cervicitis or cervical erosion. Since the presence of trichomonads may interfere with the accurate assessment of cytological smears, additional strokes should be performed after the eradication of the parasite. Treatment of a spouse without clinical manifestations. Partners without symptoms of the disease should be treated simultaneously in order to prevent re-infection. The decision to treat a male partner without clinical manifestations, in which trichomonads have not been detected (or the analysis has not been carried out), is taken by the doctor. In case of repeated infection, the spouses should be treated with buy metronidazole without prescription simultaneously.
Amoebiasis. Treatment of acute intestinal amoebiasis (amoebic dysentery) and liver abscess caused by amoebas (including aspiration or drainage of the abscess). Anaerobic bacterial infections, including infections caused by Bacteroides, including B. fragilis (B. fragilis, B.distasonis, B. ovatus, B.thetalotaomicron, B. vulgatus), Clostridium spp., Eubacterium spp., Peptococcus niger and Peptostreptococcus. Treatment of severe infections caused by sensitive anaerobic bacteria in combination with surgical treatment. In the case of mixed aerobic and anaerobic infections, antibacterial agents active against aerobic bacteria flagyl without prescription are additionally used. Infections of the skin and appendages caused by Bacteroides (including B. fragilis), Clostridium spp., Peptococcus niger, Peptostreptococcus spp. And Fusobacterium spp.
Gynecological infections, including endometritis, endomyometritis, tubo-ovarian abscess and infections after gynecological operations, caused by Bacteroides (including B. fragilis), Clostridium spp., Peptococcus niger, Peptostreptococcus spp. Bacterial septicemia caused by Bacteroides buy flagyl over the counter (including B. fragilis), Clostridium spp. Infections of bones and joints caused by species of Bacteroides (including B. fragilis), as an additional therapy. Infections of the central nervous system, including meningitis and brain abscess, lower respiratory tract infections, including pneumonia order flagyl online, empyema and lung abscess; Endocarditis caused by Bacteroides (including B. fragilis).
Hypersensitivity, leukopenia (including in the anamnesis), organic lesions of the central nervous system (including epilepsy), liver failure (in the case of high doses), pregnancy (I trimester), lactation period; Children's age (up to 3 years).
Pregnancy (II - III trimesters), renal / hepatic insufficiency. Method of administration and dosing regimen Is taken orally, during or after a meal (or with milk), without chewing. Trichomoniasis in women and men. The course of treatment with non prescription flagyl is chosen individually. One-day course of treatment - 2 grams (8 tablets) in a single dose or separately for two meals of 1 gram (4 tablets) 2 times a day. One-day treatment is indicated in cases where there is an assumption that the patient can not strictly follow the treatment regimen; The seven-day course of treatment is 250 mg (½ tablets) three times a day for seven days. The frequency of cure may be higher after a seven-day course of treatment.
Pregnant women taking where can i buy metronidazole over the counter during the first trimester of pregnancy is contraindicated. Carrying out a one-day course of therapy for pregnant women is contraindicated, since it leads to a high concentration of buy flagyl over the counter in the blood plasma and can penetrate the fetus. With repeated courses of treatment with buy metronidazole otc, it is recommended to take a break in 4 to 6 weeks. Before and after these courses, it is necessary to perform a blood test for the total number of leukocytes and a leukocyte formula.
Adults: with intestinal amoebiasis 750 mg (1½ tablets) orally three times a day for 5-10 days; With a liver abscess of 500 mg or 750 mg three times a day for 5 to 10 days. Children: daily dose of 35 to 50 mg / kg divided into three oral doses within 10 days.
For the treatment of severe anaerobic bacterial infections, buy metronidazole 500mg is prescribed at the initial stage. The usual adult dose is 7.5 mg / kg every six hours inside (about 500 mg for a patient weighing 70 kg). The maximum daily dose is 4 g. The duration of therapy is from 7 to 10 days (treatment of infections of bones and joints, lower respiratory tract and endocardium may be longer). In elderly patients, the pharmacodynamics of buy metronidazole online may be altered, monitoring of the metronidazole content in serum is necessary in order to select a dose.
In patients with severe liver disease, cumulation of where to buy metronidazole is possible and its doses should be reduced. It is recommended that the level of buy metronidazole over the counter be carefully monitored in the plasma and signs of toxicity. When anuria is not required to reduce the dose, as buy flagyl online cheap and its metabolites, are derived by dialysis.
Frequent adverse reactions:
Increases the effect of indirect anticoagulants, which leads to an increase in prothrombin time. Similarly, disulfiram causes intolerance to ethanol. Simultaneous use with disulfiram can lead to the development of various neurologic symptoms (the interval between admission is at least 2 weeks). Cimetidine suppresses buy metronidazole otc metabolism, which can lead to an increase in serum concentrations and an increased risk of side effects.
Simultaneous administration of agents stimulating enzymes of microsomal oxidation (phenobarbital, phenytoin) can accelerate the elimination of over the counter metronidazole and reduce its concentration in plasma. At simultaneous reception with preparations of lithium (Li +) concentration of the last in plasma and development of symptoms of an intoxication can raise. It is not recommended to combine with nondepolarizing muscle relaxants (vecuronium bromide). Sulfonamides increase the antimicrobial effect of buy metronidazole over the counter.
During the period of treatment, ethanol intake is contraindicated (development of disulfiram-like reactions is possible: abdominal pain of spastic nature, nausea, vomiting, headache, sudden tides of blood to the face).
With prolonged therapy, it is necessary to monitor the picture of peripheral blood. With leukopenia, the possibility of continuing treatment depends on the risk of developing the infectious process. The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment. Can immobilize treponema and lead to Nelson's false positive test.
Metronidazole may affect the determination of biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase over the counter flagyl cheap price (LDH), triglycerides, hexokinase glucose. Stains urine in a dark color.
In the treatment of trichomonas vaginitis in women and trichomoniasis in men, it is necessary to abstain from sexual activity. After the therapy, control tests should be performed for 3 consecutive cycles before and after menstruation.
The use of metronidazole otc during the first trimester of pregnancy is contraindicated. In II - III trimesters, if necessary, buy metronidazole cheap may be given taking into account the benefit / risk. Can you buy metronidazole over the counter has a teratogenic effect, it penetrates the placental barrier and quickly enters the fetal bloodstream. Adequate and well-controlled studies in pregnant women have not been conducted. Due to the fact that buy flagyl online without prescription is carcinogenic in rodents, this remedy can be used during pregnancy only in case of emergency.
The use of metronidazole during the first trimester of pregnancy is contraindicated. In II - III trimesters, if necessary, buy metronidazole without prescription may be given taking into account the benefit / risk. Metronidazole has a teratogenic effect, it penetrates the placental barrier and quickly enters the fetal bloodstream. Adequate and well-controlled studies in pregnant women have not been conducted. Due to the fact that buy flagyl online over the counter is carcinogenic in rodents, this remedy can be used during pregnancy only in case of emergency.
The use of metronidazole for sale for the treatment of trichomoniasis during pregnancy should be limited to cases in which alternative treatment is ineffective. If it is necessary to prescribe otc metronidazole during lactation, breastfeeding should be discontinued. Metronidazole over the counter equivalent is secreted into human milk in concentrations corresponding to those contained in plasma. Impact on the ability to drive and potentially dangerous machinery Possible development of dizziness, confusion, hallucinations or convulsions associated with taking this drug, which violates the operator activity.
Symptoms: nausea, vomiting, ataxia; When receiving as a radiosensitizing agent - convulsions, peripheral neuropathy.
Treatment: a specific antidote is absent, symptomatic and supportive therapy.